First Pig Liver Transplanted Into a Person Lasts for 10 Days
In a milestone for the transplantation of animal organs into people, a 50-year-old clinically dead man in China has become the first person to receive a liver from a pig. With consent from the man’s...
View ArticleBreaking Physical Barrier of Fibrotic Breast Cancer for Photodynamic...
Investigators developed FPC@S, a photodynamic immunomodulator that targeted the ECM, to improve the photodynamic immunotherapy for fibrotic breast cancer. FPC@S combined a tumor ECM-targeting peptide,...
View ArticleHuman Dental Pulp Stem Cells Derived Extracellular Matrix Promotes...
Researchers investigated the efficacy of decellularized ECM derived from human dental pulp stem cells and gingival-derived MSCs as an inductive scaffold for osteogenic differentiation of GSCs....
View ArticleNoggin Promotes Osteogenesis in Human Adipose-Derived Mesenchymal Stem Cells...
The authors showed that in osteogenic cultures of adipose-derived stem cells, Noggin activated fibroblast growth factor receptors (FGFRs), Src/Akt and ERK kinases, and it stabilized TAZ proteins in the...
View ArticleBone Marrow-Derived Mesenchymal Stem Cells Mitigate Chronic Colitis and...
Scientists investigated the therapeutic potential of bone marrow-derived MSCs treatments in spontaneous chronic colitis using the Winnie mouse model which closely replicated the presentation and...
View ArticleCutting-Edge CAR-T Cancer Therapy Is Now Made in India — at One-Tenth the Cost
A small Indian biotechnology company is producing a home-grown version of a cutting-edge cancer treatment known as CAR T-cell therapy that was pioneered in the United States. A single treatment of...
View ArticleThe Role of Matrix Metalloproteinase-2 and miR-196a2 in Bronchial Asthma...
Researchers investigated the underlying mechanisms and clinical relevance of miR-196a2 and MMP-2 serum levels in relation to the severity of asthma. [Heliyon] Full Article
View ArticlePeptide-Triggered IL-12 and IFN-γ Mediated Immune Response in CD4+ T-cells...
Scientists reported newly designed tripeptides that were able to trigger proinflammatory cytokine (IL-12 and IFN-γ) secretion by CD4+CD44+ T cells in response to Leishmania donovani infection....
View ArticleMonocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune...
Researchers used systems biology approaches including proteomics, transcriptomics, and mass cytometry to define the circulating proteome and circulating immune cell phenotypes in subjects with...
View ArticleMpox-Specific Immune Responses Elicited by Vaccination or Infection in People...
Investigators improved their understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and the long-lasting durability of childhood smallpox vaccination-mediated immune...
View ArticleNovel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower...
Scientists investigated the effects of glucagon-like peptide 1 (GLP-1) on angiogenesis of endothelial progenitor cells (EPCs) and type 1 diabetes mice, as well as its interaction with the classical...
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